What SEC filings does Alnylam Pharmaceuticals, Inc. submit to the SEC?

Alnylam Pharmaceuticals, Inc. (ALNY) submits several types of SEC filings including Form 4 (insider transactions), Form 144 (proposed insider sales), 8-K reports (material events such as earnings releases, acquisitions, leadership changes), and periodic reports — the 10-Q (quarterly) and 10-K (annual). All filings are publicly available through SEC EDGAR.

What does a Form 4 filing tell me about ALNY?

A Form 4 for ALNY discloses a transaction by a company insider — typically a director, officer, or 10%+ shareholder. It shows the source-reported date, number of shares, price, and updated ownership. These facts do not establish motive or predict future returns.

How do I interpret an 8-K filing from Alnylam Pharmaceuticals, Inc.?

An 8-K signals a material event requiring prompt disclosure. Common triggers include earnings pre-announcements, acquisitions, leadership appointments or departures, credit changes, or regulatory actions. Read the item codes inside the filing to understand exactly what was disclosed before drawing conclusions.

What is the difference between a 10-K and 10-Q for ALNY?

The 10-K is Alnylam Pharmaceuticals, Inc.'s annual report with fully audited financial statements, comprehensive MD&A, and complete risk factor disclosures — filed 60–90 days after fiscal year-end. The 10-Q is a lighter quarterly report with unaudited financials filed for the first three quarters. Together they provide a continuous financial picture of the company.

Where can I see all ALNY SEC filings directly on EDGAR?

You can view all historical Alnylam Pharmaceuticals, Inc. filings on the SEC EDGAR company page for ALNY. Each filing card on this page links directly to the original SEC document.

How often does Alnylam Pharmaceuticals, Inc. file with the SEC?

Alnylam Pharmaceuticals, Inc. files one 10-K per year and up to three 10-Qs per year. Form 4 insider transactions must be reported within two business days of each trade, so the frequency depends on how often insiders are buying or selling ALNY shares. 8-K filings occur whenever a material event happens — which can be several times per quarter for an active company.

ALNY SEC Filing News — Alnylam Pharmaceuticals, Inc.

Latest SEC filings for Alnylam Pharmaceuticals, Inc. (ALNY) explained in plain English. Covers insider buying and selling (Form 4), proposed insider sales (Form 144), material company events (8-K), and quarterly & annual reports (10-Q / 10-K). StrongBuyAnalytics provides navigation and brief excerpts or summaries; original filings remain at the SEC/source links and were authored by their filers, not StrongBuyAnalytics. Filing dates shown are source dates. Coverage and detection can be delayed or incomplete because of SEC availability, amendments, parsing, caching, or outages. Latest source filing date shown: 2026-10-06.

Alnylam Pharmaceuticals, Inc. discovers, develops, manufactures, and commercializes therapeutics based on ribonucleic acid interference in the United States, Europe, and internationally. The company offers ONPATTRO for hereditary transthyretin-mediated (hATTR) amyloidosis; AMVUTTRA for ATTR and hATTR amyloidosis; Leqvio for hypercholesterolemia; Qfitlia for hemophilia A or B; GIVLAARI for acute hepatic porphyria; and OXLUMO for primary hyperoxaluria type 1. It also develops a range of products i…

Sector: Healthcare Industry: Biotechnology Market Cap: $31.2B CIK: 1178670

Total Filings

Bullish Classifications

Bearish Classifications

Insider Transactions

Material Events (8-K)

Periodic Reports

Rule-based classifications for ALNY currently lean bearish. Of the 20 filing records displayed, 2 carry bearish classifications (such as insider sales or negative 8-K disclosures) versus 0 bullish. This does not necessarily signal fundamental deterioration — insiders sell for many reasons — but it is worth monitoring alongside the company's core financial metrics.

ALNY Filing Activity Snapshot 2026-04-30 — 2026-10-06

Insider Transactions (Form 4)

0 buys vs 2 sells

Net insider selling in this period — insiders sell for many reasons beyond conviction.

Largest Form 144 Filing

$1.15M

PYOTT DAVID E I · 2026-06-01

3,830 shares · Form 144

Form 144 Notices

Proposed insider sales filed — Form 144 is a notice of intent, not a confirmed transaction. Actual sales are confirmed via Form 4.

Insider Transactions 14 · Forms 3, 4 and 5

A Form 4 is filed within two business days of a company insider — an officer, a director, or a holder of more than ten percent of the stock — changing their position in the shares. All 14 filings in this group are Form 4s for Alnylam Pharmaceuticals, Inc.

The difficulty with reading these filings as a group is that a single form type covers transactions that mean entirely different things. An executive spending their own money to buy stock and an executive having shares withheld to pay tax on a vesting grant both appear as a Form 4. Every filing below is therefore tagged with the nature of the underlying transaction, taken from the transaction code reported on the form itself.

Across the 14 insider filings shown, the breakdown is 11 compensation award, 2 open-market sale and 1 option exercise. 2 of them involved a discretionary open-market trade; the rest are compensation and administrative mechanics.

What each transaction type means

Compensation award ×11: Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.
Open-market sale ×2: The insider sold shares on the open market. Sales may be discretionary or executed automatically under a pre-arranged Rule 10b5-1 trading plan, and a Form 4 does not always make clear which applies.
Option exercise ×1: The insider converted options into shares. The exercise price was fixed when the options were granted, so the timing usually tracks an expiry schedule.

Form 4 Open-market sale Insider Selling 2026-10-06

ALNY insider SUPRAN BRYAN (EVP, CLO and Secretary) sold 1,758 shares (~$398.9K)

SUPRAN BRYAN, listed as EVP, CLO and Secretary at ALNYLAM PHARMACEUTICALS, INC., reported an open-market sale of 1,758 ALNY shares in a Form 4 filing. This is a confirmed insider sale, not just a proposed sale notice.

The insider sold shares on the open market. Sales may be discretionary or executed automatically under a pre-arranged Rule 10b5-1 trading plan, and a Form 4 does not always make clear which applies.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`S`	Open-market sale	1,758	$226.88	$398.9K

Filing: Form 4 (Insider Transaction) Insider: SUPRAN BRYAN (EVP, CLO and Secretary) Shares: 1,758 Est. Value: $398.9K

View on SEC EDGAR → Open Filing Document →

Form 4 Compensation award Tax / Compensation Filing 2026-09-22

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

Greenstreet Yvonne (Director, Chief Executive Officer) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`A`	Compensation award	107	—	—

Filing: Form 4 (Insider Transaction) Insider: Greenstreet Yvonne (Director, Chief Executive Officer) Shares: 107

View on SEC EDGAR → Open Filing Document →

Form 4 Open-market sale Insider Selling 2026-06-03

ALNY insider PYOTT DAVID E I (Director) sold 3,830 shares (~$1.15M)

PYOTT DAVID E I, listed as Director at ALNYLAM PHARMACEUTICALS, INC., reported an open-market sale of 3,830 ALNY shares in a Form 4 filing. This is a confirmed insider sale, not just a proposed sale notice.

The insider sold shares on the open market. Sales may be discretionary or executed automatically under a pre-arranged Rule 10b5-1 trading plan, and a Form 4 does not always make clear which applies.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`M`	Option exercise	3,830	—	—
`S`	Open-market sale	921	$297.71	$274.2K
`S`	Open-market sale	1,175	$298.91	$351.2K
`S`	Open-market sale	1,222	$299.87	$366.4K
`S`	Open-market sale	495	$300.72	$148.9K
`S`	Open-market sale	17	$302.65	$5.1K
`M`	Option exercise derivative · Stock Option (Right to Buy)	3,830	—	—

Filing: Form 4 (Insider Transaction) Insider: PYOTT DAVID E I (Director) Shares: 3,830 Est. Value: $1.15M

View on SEC EDGAR → Open Filing Document →

Form 4 Compensation award Tax / Compensation Filing 2026-06-03

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

Cravatt Benjamin (Director) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`A`	Compensation award derivative · Stock Option (Right to Buy)	4,393	—	—

Filing: Form 4 (Insider Transaction) Insider: Cravatt Benjamin (Director)

View on SEC EDGAR → Open Filing Document →

Form 4 Compensation award Tax / Compensation Filing 2026-05-22

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

Sigal Charles Elliott (Director) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`A`	Compensation award	671	—	—
`A`	Compensation award derivative · Stock Option (Right to Buy)	1,441	—	—

Filing: Form 4 (Insider Transaction) Insider: Sigal Charles Elliott (Director) Shares: 671

View on SEC EDGAR → Open Filing Document →

Form 4 Compensation award Tax / Compensation Filing 2026-05-22

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

SCHULMAN AMY W (Director) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`A`	Compensation award	838	—	—
`A`	Compensation award derivative · Stock Option (Right to Buy)	1,802	—	—

Filing: Form 4 (Insider Transaction) Insider: SCHULMAN AMY W (Director) Shares: 838

View on SEC EDGAR → Open Filing Document →

Form 4 Compensation award Tax / Compensation Filing 2026-05-22

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

Reitan Colleen F (Director) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`A`	Compensation award	671	—	—
`A`	Compensation award derivative · Stock Option (Right to Buy)	1,441	—	—

Filing: Form 4 (Insider Transaction) Insider: Reitan Colleen F (Director) Shares: 671

View on SEC EDGAR → Open Filing Document →

Form 4 Compensation award Tax / Compensation Filing 2026-05-22

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

PYOTT DAVID E I (Director) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`A`	Compensation award	671	—	—
`A`	Compensation award derivative · Stock Option (Right to Buy)	1,441	—	—

Filing: Form 4 (Insider Transaction) Insider: PYOTT DAVID E I (Director) Shares: 671

View on SEC EDGAR → Open Filing Document →

Form 4 Compensation award Tax / Compensation Filing 2026-05-22

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

KELLOGG PETER N (Director) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`A`	Compensation award	671	—	—
`A`	Compensation award derivative · Stock Option (Right to Buy)	1,441	—	—

Filing: Form 4 (Insider Transaction) Insider: KELLOGG PETER N (Director) Shares: 671

View on SEC EDGAR → Open Filing Document →

Form 4 Compensation award Tax / Compensation Filing 2026-05-22

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

HAMBURG MARGARET A (Director) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`A`	Compensation award	671	—	—
`A`	Compensation award derivative · Stock Option (Right to Buy)	1,441	—	—

Filing: Form 4 (Insider Transaction) Insider: HAMBURG MARGARET A (Director) Shares: 671

View on SEC EDGAR → Open Filing Document →

Form 4 Compensation award Tax / Compensation Filing 2026-05-22

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

BRANDICOURT OLIVIER (Director) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`A`	Compensation award	671	—	—
`A`	Compensation award derivative · Stock Option (Right to Buy)	1,441	—	—

Filing: Form 4 (Insider Transaction) Insider: BRANDICOURT OLIVIER (Director) Shares: 671

View on SEC EDGAR → Open Filing Document →

Form 4 Compensation award Tax / Compensation Filing 2026-05-22

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

Ausiello Dennis A (Director) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`A`	Compensation award	671	—	—
`A`	Compensation award derivative · Stock Option (Right to Buy)	1,441	—	—

Filing: Form 4 (Insider Transaction) Insider: Ausiello Dennis A (Director) Shares: 671

View on SEC EDGAR → Open Filing Document →

Form 4 Compensation award Tax / Compensation Filing 2026-05-22

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

Arbuckle Stuart A (Director) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

Shares were granted as compensation rather than purchased. No cash changed hands, so the filing reflects a pay decision by the company, not a judgement about the price.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`A`	Compensation award	671	—	—
`A`	Compensation award derivative · Stock Option (Right to Buy)	1,441	—	—

Filing: Form 4 (Insider Transaction) Insider: Arbuckle Stuart A (Director) Shares: 671

View on SEC EDGAR → Open Filing Document →

Form 4 Option exercise Tax / Compensation Filing 2026-05-14

ALNY insider Form 4 filed for equity award, exercise, or tax withholding

SCHULMAN AMY W (Director) filed a Form 4 covering compensation-related activity such as stock awards, option exercises, conversions, or tax withholding. These filings are usually neutral.

The insider converted options into shares. The exercise price was fixed when the options were granted, so the timing usually tracks an expiry schedule.

Transactions reported on this filing
Code	Nature	Shares	Price	Value
`M`	Option exercise	11,250	$70.20	$789.8K
`M`	Option exercise derivative · Stock Option (Right to Buy)	11,250	—	—

Filing: Form 4 (Insider Transaction) Insider: SCHULMAN AMY W (Director) Shares: 11,250

View on SEC EDGAR → Open Filing Document →

Proposed Insider Sales 2 · Form 144

A Form 144 is a notice of intent to sell restricted or control securities. It is not a record that anything was sold. Alnylam Pharmaceuticals, Inc. has 2 such notices in this period.

The distinction matters because a Form 144 is frequently reported as though it were a completed insider sale. The filer may sell all of the shares covered, some of them, or none at all, and there is no obligation to update the notice either way. A sale that is actually executed by an officer or director shows up separately on a Form 4, which is the filing to check before treating a proposed sale as a real one.

Form 144 Proposed Insider Sale 2026-10-02

ALNY Form 144 filed for proposed insider sale by SUPRAN BRYAN (1,758 shares) ~$398.9K

SUPRAN BRYAN filed a Form 144 with the SEC indicating intent to sell ALNY (ALNYLAM PHARMACEUTICALS, INC.) shares. Form 144 reflects a proposed sale, not a completed transaction. The actual execution, if any, would typically appear later in a Form 4.

Filing: Form 144 (Proposed Sale Notice) Insider: SUPRAN BRYAN Shares: 1,758 Est. Value: $398.9K

View on SEC EDGAR → Open Filing Document →

Form 144 Proposed Insider Sale 2026-06-01

ALNY Form 144 filed for proposed insider sale by PYOTT DAVID E I (3,830 shares) ~$1.15M

PYOTT DAVID E I filed a Form 144 with the SEC indicating intent to sell ALNY (ALNYLAM PHARMACEUTICALS, INC.) shares. Form 144 reflects a proposed sale, not a completed transaction. The actual execution, if any, would typically appear later in a Form 4.

Filing: Form 144 (Proposed Sale Notice) Insider: PYOTT DAVID E I Shares: 3,830 Est. Value: $1.15M

View on SEC EDGAR → Open Filing Document →

Material Events 2 · Form 8-K

An 8-K reports a material event in the window between scheduled reports. There are 2 in this period for Alnylam Pharmaceuticals, Inc. Each 8-K names the item number it is filed under, and that number is the fastest way to tell a routine disclosure from a consequential one.

Item 2.02 is an earnings release, Item 5.02 is a change of directors or officers, and Item 1.01 or 2.01 covers a material agreement or a completed acquisition. Item 7.01 and Item 8.01 are the general-purpose disclosure items and carry no fixed meaning on their own.

Form 8-K Material Company Update 2026-07-30

ALNY filed 8-K — material company event

ALNYLAM PHARMACEUTICALS, INC. filed an 8-K with the SEC reporting a material event. Summary unavailable — view the original SEC filing for the full text.

Filing: 8-K (Material Event)

View on SEC EDGAR → Open Filing Document →

Form 8-K Material Company Update 2026-05-27

ALNY filed 8-K — material company event

ALNYLAM PHARMACEUTICALS, INC. filed an 8-K with the SEC reporting a material event. Summary unavailable — view the original SEC filing for the full text.

Filing: 8-K (Material Event)

View on SEC EDGAR → Open Filing Document →

Periodic Reports 2 · Forms 10-K and 10-Q

The periodic reports are where the audited and reviewed financial statements live. This period contains 2 quarterly reports (10-Q) for Alnylam Pharmaceuticals, Inc.

The two are not equivalent in weight. A 10-K is audited by an external firm and includes the full risk factor disclosure, business description and management discussion; a 10-Q is unaudited, reviewed rather than examined, and much shorter. When a figure in a quarterly report is later revised, the annual report is usually where the correction appears.

An amended report — 10-K/A or 10-Q/A — restates or corrects something in the original filing, and is worth reading against the version it replaces.

Form 10-Q Quarterly Report 2026-07-30

ALNY filed Quarterly Report (10-Q)

ALNYLAM PHARMACEUTICALS, INC. filed its quarterly report with the SEC. This report includes unaudited financial statements and management discussion for the quarter.

Filing: 10-Q (Quarterly Report)

View on SEC EDGAR → Open Filing Document →

Form 10-Q Quarterly Report 2026-04-30

ALNY filed Quarterly Report (10-Q)

ALNYLAM PHARMACEUTICALS, INC. filed its quarterly report with the SEC. This report includes unaudited financial statements and management discussion for the quarter.

Filing: 10-Q (Quarterly Report)

View on SEC EDGAR → Open Filing Document →

How we classify Alnylam Pharmaceuticals, Inc.'s filings

Straight from EDGAR

Each displayed record links to an original source document. StrongBuyAnalytics provides navigation and brief excerpts or summaries, not the filing itself. Parsing may omit context or contain errors, so read the original document in full.

Transaction codes, not guesswork

The nature shown on each insider filing comes from the transaction code the filer entered on the form itself — P for an open-market purchase, A for a compensation award, F for shares withheld to pay tax, M for an option exercise. Where one filing contains several codes, the transaction table lists them line by line.

Why the distinction matters

Insider activity is routinely summarised as buying or selling, which flattens together decisions that mean very different things. Shares withheld for tax on a vesting grant are an automatic administrative step; shares bought on the open market are someone committing their own money at the current price.

What this page does not tell you

A filing records what happened, not why. Form 4 does not always disclose whether a sale was executed under a pre-arranged Rule 10b5-1 plan, and no single filing is a basis for a decision on ALNY. Read these alongside the fundamentals rather than in isolation.

Frequently Asked Questions — ALNY SEC Filings

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Publisher, sources & limitations — September 15, 2026. StrongBuyAnalytics provides navigation and brief excerpts or summaries for educational use. Original filings remain at SEC EDGAR or other displayed source links; StrongBuyAnalytics does not author them. Filing dates are source dates, not publication dates for this page. Coverage can be delayed, incomplete, amended, or unavailable because of SEC/source availability, parsing, caching, or outages. Verify every material statement in the original filing.

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